The Pasco County Sheriff's Office said 16-year-old Payton Jeanfils ran away from home around 4:30 a.m. Friday morning.
She was last seen in the Rainbow Lane area of Port Richey.
Payton is 5 feet, 5 inches tall and weighs 150 pounds. She has black and blue hair, and brown eyes.
The teen was last seen wearing a white sweatshirt and gray sweatpants.
Anyone with information on Payton's whereabouts is asked to call the sheriff's office at 727-847-8102, option 7.