One westbound lane of Interstate 4 near Polk Parkway remains closed at this time. The crash occurred around 3:30 a.m.
According to the Polk County Sheriff's Office, two vehicles were involved and two people were taken to a hospital. One patient has serious injuries.
The view from Florida’s traffic cameras during the rush hour showed traffic was at a standstill. The collision involved a semi-truck, which caught fire.
Officials said it also led to a diesel fuel spill.
The cause of the crash remains under investigation.
This story is developing. Check back for updates.